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Weeks 5 Through 12: Accelerated Progress As the dose titrates upward according to your personalized protocol, weight loss begins to accelerate noticeably

Many patients report reduced appetite and feeling satisfied with smaller portions within the first few days of starting GLP-1 therapy

Considerations that typically inform the decision include: Primary goal: weight management, glycemic control, or both Tolerability: how each medication's side effects affect you personally Medical history: contraindications, comorbidities, and concurrent medications Cardiovascular data: semaglutide has longer-established outcome evidence Access and cost: insurance coverage, pricing, and local supply Formulation preference: injection versus, for semaglutide, an oral diabetes option A practical way to think about it: tirzepatide's dual mechanism gives it an edge in average efficacy, while semaglutide offers a longer real-world track record and additional formulation flexibility

In addition, FAERS may include duplicate reports or may significantly undercount injuries